Quantification of Collagen
2009 Bingham Proposal
Together with undergraduate students, Dr. Todd Johnson from the chemistry department and Dr. Barbara Trask from the zoology department are proposing a collaborative project to develop novel techniques using relatively inexpensive reagents and equipment to quantify the amount of collagen in mouse skin. Working with a zoology student this past summer, Dr. Trask began characterizing a strain of transgenci mice in which a gene that has been shown to affect the normal production and export of collagen has been deleted. They found that dermal wounds in these genetically altered mice healed at a rate different from those in normal mice. She would like to continue this work investigating the nature of scar formation in the healed wounds of these genetically altered mice and compare it with the scar tissue in normal mice.
While there are greater than twenty different forms of collagen, when grouped together, the collagens represent the most abundant extracellular protein in all mammals, including humans.
The outcome of this research will likely be generally applicable in the understanding of wound healing and fibrosis.